HDAC1 and metabolic dysfunction-associated steatotic liver disease: When we restricted the analysis only to genes and proteins in significantly enriched multi-omic pathways and networks, we identified 13 genes with GWAS SNPs, including FABP1 (associated with NAFLD) in PPARA and HDAC1 networks; GOT2 (associated with triglycerides and aspartate aminotransferase) in the sirtuin signaling pathway; and ATG7 (associated with fat body mass) in the sirtuin signaling pathway and KLF15 network (Table 2).