The present study has focused on oxidative stress‐related parameters and Keap1 rs11085735 variants in T2DM and its complications, diabetic neuropathy and diabetic retinopathy, and possible association between Keap1 variants with oxidative stress parameters, T2DM and the development of neuropathy and retinopathy in T2DM patients. Here, KEAP1 is linked to diabetic neuropathy.