Indeed, we found that, globally, IgM or IgG levels are increased upon infection with SARS-CoV-2, with 66% of individuals having aPL against ≥1 antigen (non-infected controls: 15%), 40% against ≥2 antigens (non-infected controls: 0%), and 21.3% against ≥3 antigens (non-infected controls: 0%), using a threshold of OD ≥ 50. This evidence concerns the gene CD40LG and infection.