2019). As an example, activation of Nrf2 reportedly interacted transcriptional coactivator small v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog proteins to impair erastin- and sorafenib-induced ferroptosis in hepatocellular carcinoma cells (Sun et al. 2016). Furthermore, Nrf2 relieved acute lung injury and intestinal ischaemia reperfusion damage by inhibiting ferroptosis, suggesting that Nrf2 acted as a central switch in regulating ferroptosis (Dong et al. 2020). Here, NFE2L2 is linked to hepatocellular carcinoma.