More importantly, a strikingly higher concentration of plasma Wnt5A was found in SLE patients with AD (5.78 ± 0.69 ng/mL) in comparison with those with LDA (2.02 ± 0.14 ng/mL) (p < 0.0001) (Fig. 2A). This evidence concerns the gene WNT5A and systemic lupus erythematosus.