Interestingly, association analysis of plasma or urine Wnt5A and clinical other serological biomarkers showed the plasma Wnt5A was positively correlated with SLE serological marker dsDNA (r = 0.4233, p < 0.0001) and the urine Wnt5A was positively correlated with anti-C1q antibody (r = − 0.2389, p = 0.0033) (Fig. 3B). The gene discussed is WNT5A; the disease is systemic lupus erythematosus.