Owing to the Wnt5A which has recently emerged as a macrophage that triggers inflammation, there are several studies supporting significant progress which has been made in investigating the role of Wnt5A in various chronic inflammatory/autoimmune rheumatic diseases, including sepsis, ankylosing spondylitis (AS), rheumatoid arthritis (RA), and atherosclerosis [10]. The gene discussed is WNT5A; the disease is rheumatoid arthritis.