In this sense, the adiponectin receptors AdipoR1 and AdipoR2 (which, like OR83B, have an inverted membrane topology) are decreased in animal models of obesity and type 2 diabetes (Yamauchi et al. 2007; Okada-Iwabu et al. 2015). Here, ADIPOR2 is linked to obesity due to melanocortin 4 receptor deficiency.