Mice expressing a constitutively active mutant alpha-1A adrenergic receptor (ADRA1A) lived significantly longer and had cardio- and neuroprotective effects and a lower incidence of cancer compared to wild animals, while mice expressing a constitutively active mutant alpha-1B adrenergic receptor (ADRA1B) lived significantly less time and had no changes in the incidence of cancer (Doze et al. 2011; Collette et al. 2014). The gene discussed is ADRA1A; the disease is cancer.