Thus, the overexpression of AdipoR1 in the liver of a mouse model of human obesity caused an increase in the activation of the AMPK pathway, while the overexpression of AdipoR2 caused an increase in the expression of peroxisome proliferator activated receptor alpha (PPAR-α) target genes. Here, ADIPOR2 is linked to obesity due to melanocortin 4 receptor deficiency.