Furthermore, pancreas derived from KC mice fed with an ethanol‐containing diet expressed higher levels of pluripotency, and self‐renewal genes (Oct‐4, SOX‐2, cMyc, and KLF4), stem cell markers (CD24, CD44, and CD133), and N‐cadherin, and lower expression of E‐Cadherin than those derived from control mice. This evidence concerns the gene KLF4 and keratoconus.