Among them, there were significant statistical differences in endometrial endometrioid adenocarcinoma versus normal in MCM2 (P=7.82e-4), MCM3 (P=0.016), MCM4 (P=6.19e-14), MCM6 (P=0.039), MCM7 (P=2.20e-7), MCM8 (P=0.012), MCM9 (P=0.042) and MCM10 (P=0.167e-11); endometrial serous adenocarcinoma versus normal in MCM2 (P=7.02E-4), MCM3 (P=2.56E-4), MCM4 (P=7.15E-8), MCM6 (P=1.61E-5), MCM8 (P=1.09E-4); endometrial mixed adenocarcinoma vs normal in MCM2 (P=0.016), MCM4 (P=0.022) and MCM6 (P=0.043). The gene discussed is MCM2; the disease is endometrial serous adenocarcinoma.