However, some MOPD1/TALS and Roifman syndrome patients (caused by mutations in RNU4ATAC) present with cardiac defects, including coarctation of aorta, Tetralogy of Fallot, atrial septal defect, ventricular septal defect and non-compaction of the heart. The gene discussed is RNU4ATAC; the disease is Abnormal cardiac septum morphology.