CACNA1C and heart failure: Besides DCM and heart failure, it will be interesting to investigate a possible contributing role for minor intron retention in (inherited) cardiac disorders in which the electrical activity of the heart is affected, such as for instance Brugada syndrome (which is associated with mutations in SCN5A and CACNA1C), and arrhythmogenic cardiomyopathy, disorders with an increasingly recognized complex genetic basis (Cerrone et al., 2019).