Since some components were significantly downregulated (i.e. RNU4ATAC, SNRNP25, SNRNP35), whereas others were upregulated (i.e. RNPC3) in DCM, it is difficult to predict whether the downstream effects would either represent an increase or decrease in minor intron retention. The gene discussed is RNPC3; the disease is familial dilated cardiomyopathy.