MYH14 and Facioscapulohumeral dystrophy: Combined with in vivo validations and functional investigations, our data emphasize a reduction in fibre contraction (P value < 0.0001) indicating that the muscle weakness that is typical of FSHD clinical spectrum might be associated with dysfunction of calcium release (P value < 0.0001), actin–myosin interactions, motor activity, mechano‐transduction, and dysfunctional sarcomere contractility.