In contrast to previous reports on cellular models with induced DUX4 overexpression31 or mouse model,23 we did not find any enrichment in genes related to breast, lung, colon, thyroid cancer, gliomas and leukaemia, inflammation, apoptosis, or response to oxidative stress, most of which are not associated to FSHD clinical spectrum. The gene discussed is DUX4; the disease is central nervous system cancer.