In FSHD, the vast majority of active modules retrieved with MOGAMUN converges towards a decreased expression of genes encoding proteins involved in sarcomere organization (P value 2.63e−12), actin cytoskeleton (P value 9.4e−5), myofibril (P value 2.19e−12), actin–myosin sliding, and calcium handling (with P values ranging from 7.9e−35 to 7.9e−21). This evidence concerns the gene MYH14 and Facioscapulohumeral dystrophy.