There was no correlation of CDC42 with age, gender, BMI, disease duration, RF status, ACPA status, TJC, SJC, or HAQ-DI score in RA patents (all P > 0.050, Fig. 3A–H, L), while CDC42 was negatively correlated with ESR (r =  −0.256, P = 0.012, Fig. 3I), CRP (r =  −0.314, P = 0.002, Fig. 3J), and DAS28-ESR score (r =  −0.274, P = 0.007, Fig. 3K). This evidence concerns the gene ESR1 and rheumatoid arthritis.