Further ROC curve analyses showed that Th17 cells (area under curve (AUC): 0.821, 95% confidence interval (CI): 0.750–0.892), CDC42 (AUC: 0.776, 95% CI: 0.694–0.857), and Th1 cells (AUC: 0.617, 95% CI: 0.518–0.716) all could distinguish RA patients from HC (Fig. 1D). This evidence concerns the gene CDC42 and rheumatoid arthritis.