APOE, one of the most well-known risk genes for Alzheimer’s disease, is a cholesterol carrier involved in lipid transport, and the ApoE-ɛ4 isoform involved in AD pathogenesis is associated with mitochondrial dysfunction and oxidative distress in the human brain (Yin et al. 2020); CD36 is a platelet glycoprotein which mediates the response to amyloid-beta accumulation (Khoury et al. 2003); LDLR is a low-density lipoprotein receptor associated with AD (Lämsä et al. 2008); and ABCA7 is a phospholipid transporter (Tomioka et al. 2017). Here, VLDLR is linked to early-onset autosomal dominant Alzheimer disease.