Hence, Kolpa et al. suggested that SAF-A is one of multiple proteins in the nuclear scaffold that support XIST RNA localization, providing functional redundancy in normal cells, but during transformation loss of one or more proteins that are functionally redundant to SAF-A can compromise RNA-anchoring in some cancer cells (best illustrated by Neuro2a tumor cells). The gene discussed is HNRNPU; the disease is neoplasm.