STAT3 and central nervous system cancer: It is overexpressed in GBM and studies using LAT1 targeting liposomes showed increased brain uptake in glioma models.103 One study observed a 60% increase in survival with LAT1 liposomes loaded with a STAT3 inhibitor, WP1066.104 The other study noted their LAT1 liposomes loaded with docetaxel were more cytotoxic in the gliomas of their animal model than docetaxel alone.103