Using this approach, docetaxel-loaded micelles conjugated to transferrin had a 20.8-fold increase in comparison to free docetaxel.96 A few in vivo studies have been performed targeting TfR with brain metastasis animal models and show positive results of increased drug uptake in the brain.97,98 A study by Wyatt et al assessed the permeability of transferrin-targeted nanoparticles in 3 different models of brain tumors: intracranial, intracardiac, and intravenous (tail vein). The gene discussed is TF; the disease is brain neoplasm.