KIT and cutaneous melanoma: Amplification of the genes encoding RTKs, including Kit and Pdgfra, are rare overall in cutaneous melanomas, but they are detected in up to 20% of the Triple WT subtype.6 Point mutations that activate the KIT RTK have also been detected as rare events in cutaneous melanomas, but they are detected in ≥ 20% of mucosal melanomas, which are rare but aggressive tumors that arise from mucosal surfaces throughout the body.