Among 15 human NASH-upregulated cytokines and chemokines, two cytokines CMTM2 and LTB were nonclassified, 12 out of 15 (80%) were classified in the canonical secretome, TNFSF10 was classified in canonical and exosome secretomes, and NAMPT was classified in canonical and caspase-4 secretomes (Figure 2(h)). The gene discussed is CASP4; the disease is metabolic dysfunction-associated steatohepatitis.