The datasets we analyzed include (1) the high-fat diet (HFD) and methionine- and choline-deficient (MCD) diet model (GSE35961) [49], (2) the high-fat-cholesterol diet- (HFCD-) induced diet model [50], (3) the glycine N-methyltransferase- (GNMT-) KO genetic model, (4) the liver-specific methionine adenosyltransferase 1A- (MAT1A-) KO (GSE63027) [51] genetic model, and (5) two human NASH microarrays (GSE63067 [51] and GSE17470 [52]). Here, MAT1A is linked to metabolic dysfunction-associated steatohepatitis.