The MCD+HFD model (GSE35961) had top upregulated pathways including leukocyte extravasation, antibody Fc fragment gamma (Fcγ) receptor-mediated phagocytosis, IL-8 signaling, Rac signaling, and glucose 6-phosphate (G6P) signaling, among which IL-8 signaling was shared with the second human NASH. The gene discussed is AKT1; the disease is metabolic dysfunction-associated steatohepatitis.