The HFCD model (GSE53381) has only four upregulated pathways including LXR/RXR activation and fatty acid β-oxidation I, among which LXR/RXR activation was shared with the first human NASH, fatty acid β-oxidation II was shared with the first human NASH and GNMT-KO, and nicotine degradation II was shared with MAT1A-KO. The gene discussed is MAT1A; the disease is metabolic dysfunction-associated steatohepatitis.