Mechanistically, hyperlipidemia induced by HFD feeding acts as the first stimulation for TI [98, 99] (Figure 7(a)) via lysoPC stimulation [27], oxidized low-density lipoprotein (oxLDL) binding to CD36 [100], TLR4 [5]/TLR2 [101] and nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasomes [6, 26, 99, 102, 103] (Figure 7(b)). Here, TLR4 is linked to hyperlipidemia.