Taken together, our results have demonstrated that the two human NASH datasets have diversified signaling pathways, which allow us to classify the first one into LRX/RXR activation-related metabolic NASH and the second NASH into NF-κB signaling [64]/T helper cell 17 (Th17) [56, 65] inflammatory NASH. This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatohepatitis.