By comparison, three NAFLD mouse models upregulated 32 (82.1%) specific canonical secretomic cytokines and chemokines; and human NASH upregulated 8 (53.3%) specific cytokines and chemokines including erythropoietin (EPO), IL17F, CCL8, IL27, CCL21, CXCL12, CCL15, and CCL20. Here, CXCL12 is linked to metabolic dysfunction-associated steatotic liver disease.