Among 26 NAFLD mouse-upregulated cytokines and chemokines, one was the nonclassified, 15 were classified in the canonical secretome, seven were classified in canonical and exosome secretomes, NAMPT was classified in canonical and caspase-4 secretomes, and two cytokines were classified in canonical, exosomes, and caspase-4 secretomes (Figure 2(i)). The gene discussed is CASP4; the disease is metabolic dysfunction-associated steatotic liver disease.