To determine whether NASH/NAFLD upregulated cytokines and chemokines classified into noncanonical secretomes, we collected four types of secretomes with total 11,385 proteins including canonical secretome (2641 proteins) [61], caspase-1-dependent noncanonical secretome (961 proteins) [23], caspase-4-dependent noncanonical secretome (1223 proteins) [24], and exosome secretome (6560 proteins) [25]. The gene discussed is CASP1; the disease is metabolic dysfunction-associated steatotic liver disease.