ANXA5 and COVID-19: A STRING protein network analysis (Supplementary Figure 4) showed that ITGA2B together with coagulation factor XIIIA (F13A1), annexin A5 (ANXA5) and calmodulin (CALM1)—all significantly altered in COVID-19 patients relative to healthy donors (Table 3)—significantly enriched the biological process “platelet degranulation” (p = 0.0243), thereby also confirming the recent bioinformatic meta-assessment results of several previous clinical proteomics studies of COVID-19 patients demonstrating increased platelet degranulation (47).