The strength of association of SLE with CHD and MI was particularly noteworthy: SLE patients had a 2-fold increased risk of CHD and 4-fold increased risk of MI relative to non-CID controls—even after multivariable adjustment—and SLE patients with higher CRP levels had a 12-fold higher MI risk compared with non-CID controls. The gene discussed is CRP; the disease is systemic lupus erythematosus.