The speed and magnitude of the increase in ANP was seen to be associated with a greater increase in LVEF and a decrease in the LAVI Furthermore, the speed and magnitude of the reduction in NT-proBNP and the indexed LVESV showed an impact on clinical prognosis: the probability of hospitalization for HF or death was significantly higher in patients in whom these parameters did not fall below the mean at 3 and 6 months, respectively, compared to those that did (odds ratio = 2.03; CI 95%, 1.25–3.30; p < 0.001) (55). This evidence concerns the gene NPPA and hydrops fetalis.