The investigators found that among patients with HF with HFrEF who were hospitalized for acute decompensated HF, the initiation of sacubitril/valsartan therapy led to a greater reduction in the NT-proBNP concentration than enalapril therapy (-46.7 vs.−25.3%, respectively), which was significant at 1 week after randomization (7). The gene discussed is NPPB; the disease is hydrops fetalis.