NPPB and hydrops fetalis: Similarly, NT-proBNP was used as the surrogate endpoint in the PARAMOUNT (Prospective comparison of ARNI with ARA II on Management of HF with preserved ejection fraction) trial in patients with HF and preserved ejection fraction, in which sacubitril/valsartan reduced NT-proBNP to a greater extent than valsartan at 12 weeks and was well-tolerated (71).