REN and aortic stenosis: In Stage B heart failure (structural heart abnormalities without signs and symptoms of heart failure), adverse myocardial remodeling in left ventricular hypertrophy (LVH) conditions such as hypertensive heart disease and aortic stenosis (AS) is accompanied by myocardial fibrosis that is mediated in part by myocardial injury/ischemia, neurohormones and the renin-angiotensin-aldosterone system (10, 11).