IL6 and atrial fibrillation: Recently, clinical proofs have highlighted the mechanistic link between the expression level of IL-6 and the development and prognostic of AF (52), the results suggest a declined expression of IL-6 may spur a lower incidence of AF (53), further mechanism studies have illustrated that the mutation of IL-6 and inflammatory reactions related to IL-6 are pivotal in the progress of atrial remodeling, which is one of the cores of the development of AF (54–57).