MAPT and frontotemporal dementia: The ΔK280 deletion mutant, which is known to accelerate tau aggregation and is associated with the development of frontotemporal dementia (Wegmann et al., 2011) was studied by a combination of solid-state NMR, atomic force microscopy, transmission electron microscopy (TEM) and all-atom explicit molecular dynamics simulations in the R2 peptide (Raz et al., 2014).