By univariate Cox analysis in DSS of 33 cancer types, we found that high PBK expression is associated with poorer prognosis in ACC (HR = 2.166, p < 0.001), KICH (HR = 2.336, p < 0.001), KIRC (HR = 2.215, p < 0.001), KIRP (HR = 2.867, p < 0.001), LGG (HR = 1.319, p < 0.001), LIHC (HR = 3.633, p < 0.001), LUAD (HR = 1.225, p < 0.001), MESO (HR = 1.954, p < 0.001), PCPG (HR = 4.683, p = 0.002), and SARC (HR = 1.263, p = 0.022) (Figure 4). The gene discussed is PBK; the disease is cancer.