Caloric restriction was shown to induce the accumulation of SIRT1 in murine ovaries, which is associated with inhibition of primordial follicle activation and impairment of ovarian follicle development (Tatone et al., 2015) (Liu et al., 2015) (Long et al., 2019) mechanisms probably involved in mice delay of puberty, prolongation of reproductive lifespan, and prevention of age-associated infertility (Liu M. et al., 2013). The gene discussed is SIRT1; the disease is Infertility.