These results are in good agreement with data showing that the SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling (Zhou et al., 2014). The gene discussed is SIRT1; the disease is obesity due to melanocortin 4 receptor deficiency.