With the increase of malignancy (astrocytoma (A), recurrent astrocytoma (RA), anaplastic astrocytoma (AA), recurrent anaplastic astrocytoma (rAA), oligodendroglioma (O), recurrent oligodendroglioma (rO), anaplastic oligodendroglioma (AO), glioblastoma (GBM), and recurrent glioblastoma (rGBM)), the expression of MXD3 increased significantly. This evidence concerns the gene MXD3 and anaplastic astrocytoma.