Patients meeting a proposed criteria for COVID-19-associated hyperinflammatory syndrome (including fever; ferritin and d-dimer elevation; NLR elevation or anemia/thrombocytopenia; LDH or AST elevation; and IL-6, triglyceride, or CRP elevation) were shown recently to have higher risk of requiring mechanical ventilation and higher risk of mortality (13). The gene discussed is CRP; the disease is anemia (phenotype).