Treatment of mice that had renal fibrosis with fenofibrate (a PPAR-α agonist) significantly up-regulated the expression of genes that mediate FAO [carnitine palmitoyl-transferase 1 (CPT1), carnitine palmitoyl-transferase 2 (CPT2), acyl-CoA oxidase 1 (ACOX1), and acyl-CoA oxidase 2 (ACOX2)], reduced fibrosis, and improved renal function. This evidence concerns the gene ACOX2 and renal fibrosis.