REST and neoplasm: Univariate Cox regression analysis of OS showed that WHO grade (G3–4), IDH status (WT), 1p/19q codeletion (non-codeletion), histological type (GBM), tumor status (with tumor), primary therapy outcome (SD + PD), age (>45), Karnofsky score (≤80) and high REST expression level was associated with poor OS (all p < 0.001, Table 3).