It has been found that mir-137 (47), mir-129-1 (48), and mir-873 (49) exert tumor suppressor functions in glioma, while lncRNAs, including CYTOR (50), HOTAIRM1 (51, 52), MIR4435-2HG (53), and PVT1 (54) maintain tumorigenicity and promote progression of glioma; these studies confirm the reliability of the current findings. This evidence concerns the gene HOTAIRM1 and central nervous system cancer.