REST and central nervous system cancer: In terms of the functions and pathways of REST DE-mRNAs in glioma, our results showed that BP, such as ECM organization, extracellular structure organization, and neurotransmitter transport; CC, such as collagen-containing ECM, synaptic membrane, and pre-synapse; MF, such as passive transmembrane transporter activity, channel activity, and ECM structural constituents; and pathways, such as neuroactive ligand-receptor interaction and ECM-receptor interaction were remarkably regulated by REST in glioma.