Mechanistically, through ceRNA mechanism, LINC00106 is capable of sponging and declining the expression of miR–let7f in HCC, so that under both in vivo and in vitro conditions, the stemness and metastatic properties of HCC cells can be augmented by the periostin-associated PI3K-AKT signaling pathway. Here, AKT1 is linked to hepatocellular carcinoma.