GSDMD and alcohol dependence: Additionally, the therapeutic effect of disulfiram [DSF, a Food and Drug Administration (FDA)-approved anti-alcoholism drug, is an effective pyroptosis inhibitor by either directly covalently modifying GSDMD or indirectly inhibiting the cleavage of GSDMD via inactivating Nod-like receptor protein 3 (NLRP3) inflammasome (Deng et al., 2020; Hu et al., 2020; Zhang et al., 2021)] was evaluated.