Administration of metformin decreased MICU1 expression and mitochondrial Ca2+ content, and enhanced complex I-driven respiration in a cardiomyopathy mouse model of dystrophin-deficiency, suggesting that metformin has a cardioprotective role in impaired Ca2+ homeostasis and aberrant SR/ER-mitochondria interaction (Angebault et al., 2020). The gene discussed is DMD; the disease is cardiomyopathy.