MAPT and Alzheimer disease: In addition, the authors found that differential gene expression signatures in MAPT R406W iPSC-derived neurons also had some overlap with gene expression profiles from postmortem brain tissue of patients with PSP, a related disorder and another form of FTLD-tau, but not with gene expression signatures from postmortem brain tissue of patients with AD or FLD-TDP (Jiang et al., 2018).