MAPT and Alzheimer disease: In this context, the MAPT haplotype, either H1 or H2, of donors and stem cell lines could also play an important role since the H1 MAPT haplotype is associated with a higher risk for developing PSP, CBD, AD, and Parkinson’s disease (PD) (Kwok et al., 2004; Myers et al., 2005; Hoglinger et al., 2011; Kouri et al., 2015).