Characterization of transcriptome profiles in MAPT R406W iPSC-derived neurons and in postmortem brain tissue from patients with MAPT R406W. Identification of 61 overlapping genes linked to calcium-dependent presynaptic function and GABAergic signaling; genes significantly enriched for FTD risk variants; some overlap of gene expression signatures in MAPT R406W iPSC-derived neurons with also postmortem brain tissue of PSP patients. Here, MAPT is linked to supranuclear palsy, progressive, 1.