These genes/loci are MAPT encoding tau causing FTLD-tau, GRN encoding progranulin causing FTLD-TDP, C9orf72 (chromosome 9 open reading frame 72) causing FTLD-TDP with or without motor neuron disease and representing the most common genetic alteration in ALS, VCP encoding the valosin-containing protein causing FTLD-TDP, and CHMP2B encoding the charged multivesicular body protein 2B causing FTLD-UPS. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.