Increasing evidence also demonstrated that cancer progression strongly depended on the components of the TME: the ratio of CD206+ tumor-associated macrophages/CD68+ tumor-associated macrophages, NK cells, cytotoxic T cells, and gamma delta T cells served as independent risk factors for patients with CC (Janakiram et al., 2016; Feng et al., 2019; Mlecnik et al., 2020; Lu et al., 2021). The gene discussed is MRC1; the disease is cancer.