TGFB1 and Hepatic fibrosis: In addition, the bioactive lignan can inhibit the proliferation of HSC-T6 cells, and the monomeric component schisandrin B (Sin B) has been shown block HSC activation by inhibiting TGF-β/Smad signaling pathway and reduce hepatic fibrosis progress in rats (Huang et al., 2011; Chen et al., 2013, 2017).