HMOX1 overexpression is observed in various solid malignancies, including bladder (Miyata et al., 2014), breast (Noh et al., 2013), colon (Yin et al., 2014), glioma (Gandini et al., 2014), lung (Degese et al., 2012), prostate (Maines and Abrahamsson, 1996), and gastric (Yin et al., 2012), cancers. Here, HMOX1 is linked to central nervous system cancer.