Among them, ARHGDIB (Su et al., 2019), LRRC25 (Zhang et al., 2020), PLAUR (Tan et al., 2020), and TREM1 (Kong et al., 2020) were selected as prognostic hub genes in lower grade glioma in previous bioinformatic analyses. The gene discussed is ARHGDIB; the disease is central nervous system cancer.