In falciparum malaria (Yeo et al., 2019b), vivax malaria (Barber et al., 2021), knowlesi malaria (Barber et al., 2021), and other disease settings including sepsis (Beurskens et al., 2020), Ang-2 has been associated with eGC loss, independent of other potential mediators. Here, ANGPT2 is linked to malaria.