MICA and colorectal carcinoma: In cells of healthy colon mucosa and in well-differentiated CRC, MICA/B and ULBP1 NKG2DLs are expressed mostly on the luminal part of the epithelial layer, whereas a loss of the polarization of NKG2DL expression was observed in malignant cells during the advancement of EMT (López-Soto et al., 2006; Huergo-Zapico et al., 2014).