IL-8, is a strong chemotactic factor for neutrophils which have protumorigenic and prometastatic functions as they induce intracellular adhesion molecule 1 (ICAM-1)-mediated binding of tumor cells to the surface of neutrophils and secretion of matrix metalloproteinases (MMPs) which remodel the extracellular matrix and favor tumor migration (Palena et al., 2012). Here, CXCL8 is linked to neoplasm.