ICAM1 and neoplasm: IL-8, is a strong chemotactic factor for neutrophils which have protumorigenic and prometastatic functions as they induce intracellular adhesion molecule 1 (ICAM-1)-mediated binding of tumor cells to the surface of neutrophils and secretion of matrix metalloproteinases (MMPs) which remodel the extracellular matrix and favor tumor migration (Palena et al., 2012).