There is a number of immune checkpoint molecules that contribute to immunosuppression in cancer and are upregulated on T and NK in TME as a consequence of chronic inflammation: programmed cell death receptor (PD)-1, cytotoxic T lymphocyte antigen (CTLA)-4, T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), lymphocyte activation gene-3 (LAG-3), and TIGIT (Beldi-Ferchiou and Caillat-Zucman, 2017). The gene discussed is HAVCR2; the disease is cancer.