Previous studies have reported that overexpression of EMT-related transcription factors, such as Snail, Slug, Twist1,2, ZEB1/ZEB2, and FOXC2, FOXQ1, FOXC1, and FOXM1 is associated with invasiveness, metastasis, and poor prognosis of CRC (Francí et al., 2009; Gomez et al., 2011; Zhang et al., 2013; Lu et al., 2018). This evidence concerns the gene TWIST1 and colorectal carcinoma.