TIM3, a coinhibitory or immune checkpoint receptor, interacts with multiple ligands expressed on tumor cells such as HLA-B-associated transcript 3 (BAT3), carcinoembryonic antigen-related cell adhesion molecule (CEACAM)1, phosphatydilserine on apoptotic cells, galectin-9 that is present as surface molecule or in soluble form when secreted by tumor cells, and high mobility group protein B1 (HMGB1). The gene discussed is HAVCR2; the disease is neoplasm.