Prolonged inflammation leads to loss of MHC I expression on tumor cells and can be attributed to the effect of an immunosuppressive cytokine TGF-β, IL-10, and the epidermal growth factor (EGF) which are secreted in the TME (Stanilov et al., 2010; Chen et al., 2015; Lorenzo-Herrero et al., 2018; Fedele and Melisi, 2020). The gene discussed is EGF; the disease is neoplasm.