VEGFA and neoplasm: Moreover, as NK cells exert ADCC upon recognition of the Fc fragment of IgG bound to tumor cell surface by CD16, NK cells are involved in responses to monoclonal antibody (mAb) therapies such as cetuximab (anti-EGFR mAb), bevacizumab (anti-VEGF) mAb therapy are applied in treatment of metastatic CRC (Lorenzo-Herrero et al., 2018).