HLA-G expression has been shown in CRC although its relation to EMT has not been resolved, yet (Lin and Yan, 2018). The inhibitory receptor CD94/NKG2A and its ligand HLA-E are frequently overexpressed in many types of tumors, including CRC (Zhen et al., 2013; Cózar et al., 2021). Here, KLRD1 is linked to colorectal carcinoma.