Nestin is a class VI intermediate filament protein, which is usually expressed by stem-like cells, including neural stem or progenitor cells (Bernal and Arranz, 2018), tumor stem cells (Neradil and Veselska, 2015) and MSCs of various tissues (Yin et al., 2016; Lu et al., 2019; Liao et al., 2020). This evidence concerns the gene NES and neoplasm.