For instance, a novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1 (Huang et al., 2020), and hot-star circRNA CDR1as and CircRNA0001859 are key players in balancing cardiovascular–pulmonary homeostasis (Chen S. et al., 2020; Ma et al., 2020). Here, IGF2BP1 is linked to lung adenocarcinoma.