Meanwhile, in lung cancer cells, TSK expressed more highly than the other small leucine-rich repeat proteoglycan family members and regulates the epithelial–mesenchymal transition and cell proliferation (Yamada et al., 2019; Huang et al., 2021), indicating its pivotal functions in reverting the abrogated epithelium development and retarded EC proliferation. This evidence concerns the gene TSKU and lung carcinoma.