PIK3CA and colorectal carcinoma: In addition, correlation analysis by the GEPIA database showed that the mRNA level of p21, p27, cyclin D1, Notch1, mTOR, PIK3CA, and ERBB3 were significantly associated with QSOX2, while p53 was not, indicating that QSOX2 may promote CRC cell proliferation and metastasis via some of these signaling pathways (Figure 5C).