QSOX2 and neoplasm: Table 5 showed the relationship between QSOX2 expression and clinicopathological features of the CRC patients. QSOX2 overexpression was positively associated with aggressive features of CRC, such as tumor lymph node metastasis (p = 0.048), TNM stage progression (p < 0.001), tumor diameter (p = 0.017), and distant metastasis (p = 0.008).