The best long treatment of patients with hypercalcemia, hypercalciuria, nephrocalcinosis, and nephrolithiasis due to CYP24A1 or SLC34A mutations is still unknown, but pathogenesis-based treatment consists of avoidance of vitamin D and sun exposure, hyperhydration, and a dietary recommendation of a low-sodium diet with normal calcium intake. This evidence concerns the gene CYP24A1 and nephrolithiasis.