Second, the typical patients with neonatal-onset DJS are likely to be full-term, well looking neonates who manifest with normal ALT cholestasis since the 1 week of life, which resolves within 3–6 months of age, followed by a benign course that could be punctuated by recurrent episodes of jaundice on long term follow-up (in some patients), and a direct bilirubin that do not normalize between episodes. This evidence concerns the gene GPT and Dubin-Johnson syndrome.