IPA analysis of genes which were downregulated after 3-day Listeria infection, either in both human hepatocyte models, or both human Huh7 and PMH models, also identified pathways associated with ligand-dependent nuclear receptors liver X receptor/retinoid X receptor (LXR/RXR) and farnesoid X receptor/retinoid X receptor (FXR/RXR) (Figure 2G). Here, NR1H4 is linked to listeriosis.