URA performed on the network of genes that were either deregulated by infection in Huh7 and PMH models, or in human Huh7 and HepG2 models, identified extensive overlap between the transcriptional regulators coordinating the observed patterns of gene dysregulation: the hepatocyte nuclear factors HNF1α and HNF4α, the ligand-dependent nuclear receptors PPARα, LXRβ, RXRα and RORC, and P53. The gene discussed is HNF4A; the disease is infection.