Interestingly, the epigenetic regulator SIRT2, previously associated with Listeria infection (Eskandarian et al., 2013), was predicted to regulate the expression of ten infection-dysregulated genes involved in the cholesterol biosynthetic pathway (ACLY, DHCR7, FDFT1, HMGCR, IDI1, LSS, MVD, MVK, SC5D, SQLE) (Supplementary Table S13) (Figure 7B). This evidence concerns the gene HMGCR and listeriosis.