HMGCR and infection: Interestingly, the epigenetic regulator SIRT2, previously associated with Listeria infection (Eskandarian et al., 2013), was predicted to regulate the expression of ten infection-dysregulated genes involved in the cholesterol biosynthetic pathway (ACLY, DHCR7, FDFT1, HMGCR, IDI1, LSS, MVD, MVK, SC5D, SQLE) (Supplementary Table S13) (Figure 7B).