Several cell types contribute to the defense of the infected liver against Listeria infection, in particular neutrophils, natural killer (NK) cells, dendritic cells (DC) (Conlan and North, 1991; Gregory et al., 1996; Cousens and Wing, 2000; Arnold-Schrauf et al., 2014; Witter et al., 2016) and KC, whose necroptotic death triggers the recruitment of infiltrating monocytes, which proliferate and differentiate into macrophages at the site of infection (Bleriot et al., 2015). Here, CALCA is linked to listeriosis.