Previous studies have reported that WZB117 significantly inhibits the proliferation of cancer cells by reducing the transporter function of GLUT1 (Vander Heiden et al., 2009; Koch et al., 2015; Chen et al., 2017) which was overexpressed in cancer cells (Ganapathy et al., 2009) maybe through the reduction of ATP and glycolytic enzyme levels. This evidence concerns the gene HK1 and cancer.