The role of epithelial plasticity in HCC has become more and more prominent, since inducers of EMT such as transforming growth factor (TGF-β) can drive both fibrogenesis and carcinogenesis with rising cytokine levels in cirrhosis as well as late-stage HCC (Giannelli et al., 2016). The gene discussed is TGFB1; the disease is Cirrhosis.