SDC1 and AL amyloidosis: This antibody-drug conjugate displayed in vitro and in vivo anti-tumour activity against multiple myeloma cells expressing syndecan-1, both as monotherapy (144) and in combination with other clinically approved anti-myeloma drugs (145), and more recently it has been under phase I and phase I/IIa clinical trials as monotherapy for relapsed and/or refractory multiple myeloma (146).