NDST1 and neoplasm: Additionally, Fuster M. M. et al. studied the impact of another NDST isoform, NDST1, on tumour angiogenesis, and showed that endothelial cells isolated from Ndst1 KO mice synthesized structurally modified HS chains that impaired angiogenesis-related signalling pathways, leading to decreased vascularization of lung tumours and consequent reduced tumour growth (96).