It has also been reported the anti-angiogenic efficacy of two different fluoro-xylosides that by inhibiting HS synthesis in endothelial cells, ultimately inhibit tumour cells’ angiogenesis (134), which is in agreement with the previously mentioned role of HSPGs as important binding partners and co-receptors of pro-angiogenic factors, including VEGF and FGF. The gene discussed is VEGFA; the disease is neoplasm.