found that Nrf2, a transcription factor of FPN1, inhibited the proliferation and metastasis of prostate cancer cells by up-regulating FPN1, which was also related to the reduction of intracellular ferritin content (92), and Nrf2 was able to inhibit myeloma cell proliferation by promoting FPN1 transcription (43). This evidence concerns the gene SLC40A1 and prostate carcinoma.