Other studies have shown that targeting TFR1 can suppress tumor progression, such as MiR-107 can inhibit the proliferation, migration, and invasion of SW620 cells by targeting TFR1 (34); MiR-148a could reduce the proliferation of liver cancer cells by targeting TFR1 (32); EGFR regulates cellular iron homeostasis by regulating the redistribution of TFR1, and promotes the development of non-small cell lung cancer (60). This evidence concerns the gene TFRC and liver cancer.