identified that the synthesis of hepcidin is regulated by SOSTDC1, the BMP4/7 antagonist, providing a new mechanism for cellular iron dysfunction via the E4BP4/G9a/SOSTDC1/hepcidin pathway in the thyroid gland, which can inhibit the secretion of hepcidin and proliferation of thyroid cancer cells (44). The gene discussed is SOSTDC1; the disease is thyroid cancer.