The expression STEAPs also exhibits an upregulation in tumors and they can promote tumor cell proliferation as well as suppress apoptosis (70–73), for example, STEAP3 promotes glioma cell proliferation, invasion, and spheroid formation by inducing mesenchymal transformation, promoting TFR1 expression, and activating the STAT3-FoxM1 axis (39); In colorectal cancer, STEAP3 expression is significantly higher in tumor than that in colonic mucosa (74). The gene discussed is TFRC; the disease is central nervous system cancer.