SLC11A2 and cancer: For example, DMT1 inhibitors can selectively target stem cells in primary cancer cells and circulating tumor cells to inhibit the occurrence and development of tumors (68); Propofol, which is widely used in clinical practice for intraoperative general anesthesia and postoperative sedation, regulates DMT1 expression by modifying Ca2+-permeable α-amino-3-hydroxyl-5-methylisoxazole-4-propionic acid receptors (CPARs), thereby inhibiting tumor oxidative stress and glioma tumor growth (69).