TP53 and neoplasm: The suppressive roles of FPN1 have been established in tumors, such as in prostate cancer cell lines, a low FPN1 level caused by up-regulation of ferritin promoted proliferation, migration, and apoptotic resistance, and overexpression of FPN1 induced p53 and autophagy, and reduced tumor growth in vivo (42); Overexpression of FPN1 decreased proliferation, colony formation, and tumor growth, as well as liver metastasis in breast cancer (88).