SLC40A1 and Familial prostate cancer: found that Nrf2, a transcription factor of FPN1, inhibited the proliferation and metastasis of prostate cancer cells by up-regulating FPN1, which was also related to the reduction of intracellular ferritin content (92), and Nrf2 was able to inhibit myeloma cell proliferation by promoting FPN1 transcription (43).