In contrast, three Immunogradient indicators provided the independent prognostic value in the non-amplified tumors: CD8 density in the tumor aspect of IZ (CD8_d_T) and positive IZ CD8 density gradient towards the tumor (CD8_CM) were associated with better OS, while the variance (SD) of CD8 density (CD8_d_TE_sd) along the TE predicted worse OS. Here, CD8A is linked to neoplasm.