CD8A and neoplasm: Remarkably, models 2 and 3 included the same three immune response indicators as independent prognostic factors, reflecting different properties of the local CD8 densities within tumor microenvironment: CD8_d_T (absolute density in the tumor aspect of IZ) and CD8_CM (positive IZ density gradient towards the tumor) were both associated with longer OS, while CD8_d_TE_sd (variance of the CD8 cell density along the IZ) was a feature of worse prognosis.