As a result, the ESM1 expression and pTNM stage were closely related to the prognosis of ACC patients in uni-Cox analysis (Figure 4A, all p < 0.05), while the ESM1 expression could not be served as independent prognostic factors for ACC patients in multi-Cox analysis (Figure 4B, all p > 0.05). This evidence concerns the gene ESM1 and adrenal cortex carcinoma.