ESM1 and adrenal cortex carcinoma: In this essay, the analysis of the database, Gene Expression Omnibus (GEO) GEO and Cancer Genome Atlas (TCGA) databases, coupled with the immunohistochemistry (IHC) detection of human specimens and cell line experiment, suggested that ESM1 was significantly overexpressed, associated with poor prognosis, involved in Notch signaling pathway-mediated cell cycle in ACC.