On the other hand, a longitudinal analysis of eight MBL cases by whole exome sequencing (WES) at two time points of 65 months apart, revealed that the four cases who developed detectable lymphadenopathy by physical exam yet without need for treatment carried mutations in putative CLL driver genes, including ATM, DDX3X, EGR2, FBXW7, SAMHD1 and SF3B1 (42). The gene discussed is SF3B1; the disease is B-cell chronic lymphocytic leukemia.